New blood clot research indicates improvement in un
Research from the RCSI University of Medicine and Health Sciences has revealed new insights into how blood clots form during wound healing.
The research, published tomorrow in Scientists progressexamines the behavior of platelets at a wound site, in particular their ability to sense where they are in a blood clot and reshape their environment accordingly.
Platelets are essential for initiating wound healing and the formation of blood clots (thrombus). Fibroblasts are connective tissue cells that are essential for later stages of wound healing. Fibroblasts invade the clot that has formed and produce vital proteins, including fibronectin, which then form a structural framework to build the new tissue needed for healing.
This new study indicates that platelets can also form a temporary matrix of fibronectin in their environment, similar to what fibroblasts do in the later stages of wound healing. This has potential implications for how blood clot integrity might be maintained during vascular repair.
The study’s lead author is Dr. Ingmar Schoen of RCSI’s School of Pharmacy and Biomolecular Sciences.
Commenting on the discovery, Dr Schoen said: “We have identified an additional unexpected role for the most important platelet adhesion receptor. Our results show that platelets not only form the clot, but can also initiate its remodeling by erecting a fibrous scaffold. This finding challenges some existing paradigms in the field of wound healing, which is dominated by fibroblast research.
Key to this research was the use of super-resolution microscopy, which allows sharper images of structures within or around cells to be captured and observed. in vitro, in a laboratory. Observation of this platelet behavior in a living organism (live) will be needed to further this conclusion.
“Without super-resolution microscopy, this discovery would not have been possible,” noted Dr. Schoen.
The research was conducted in collaboration with researchers from ETH Zurich, Julius-Maximilians-University Würzburg, University of Freiburg and University Hospital Zurich.
For more information:
Rosie Duffy, Communications Officer, RCSI University of Medicine and Health Sciences
+353 83 302 4611 / [email protected]
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The title of the article
Platelets drive fibronectin fibrillogenesis using integrin αIIbβ3
Publication date of articles
March 11, 2022
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